RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA
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چکیده
منابع مشابه
RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA.
RNA polymerase II (Pol II) is a well-characterized DNA-dependent RNA polymerase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity. Natural cellular RNA substrates of mammalian Pol II, however, have not been identified and the cellular function of the Pol II RdRP activity is unknown. We found that Pol II can use a non-coding RNA, B2 RNA, as both a substrate and a...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2013
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2013.18